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KMID : 0380020040190010057
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Korean Journal of Biotechnology and Bioengineering
2004 Volume.19 No. 1 p.57 ~ p.61
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Screening of Peroxynitrite and DPPH Radical Scavenging Activities from Salt Marsh Plants
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Seo Young-Hwan
Lee Hee-Jung
Kim You-A
Ahn Jong-Woong
Lee Bum-Jong
Moon Sung-Gi
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Abstract
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A peroxynitrite is formed when superoxide and nitric oxide exist at near eqimolar ratio in biological systems. Although not a free radical by chemical nature, peroxynitrite is a powerful oxidant having a wide array of tissue damaging effects ranging from lipid oxidation and inactivation of enzymes and ion channels through protein oxidation and nitration to inhibition of mitochondrial respiration. During our search for new antioxidizing components from natural resources, twenty salt marsh plants were screened for their ONOO and DPPH radical scavenging activities. Among them, methanol extract of Rosa rugosa, lxeris tamagawaensis, Erigeron annus, Tetragonia tetragonoides, Imperata cylindrica, and Suaeda japonica inhibited more than 85% of peroxynitrite produced by 3-morpholinsydnonimine (SIN-1) at a concentration of 5 /. In addition, Rosa rugosa, Artemisia capillaris, Erigeron annus and Ixeris tamagawaensis showed significant scavenging effect against DPPH (1,1-diphenyl-2-picrylhydrazyl radical).
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KEYWORD
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Salt marsh plants, peroxynitrite, DPPH, radical scavenging activity
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